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1.5.3 Molecular biology

1. Physical chemistry of biopolymers, their components and complexes. 2. DNA damage replication and repair. 3. Genome structure, genomics, epigenomics and transcriptomics. Bioinformatic methods for analyzing databases of DNA, RNA and protein sequences, including pathology in humans. 4. transcription, regulation of transcription, including epigenetic regulation, regulatory elements of the genome, regulatory networks. 5. Post-transcriptional RNA transformations (splicing, processing, transport, RNA degradation). 6. Organization of genetic material in the cell nucleus, chromatin, structural and functional compartmentalization of the cell nucleus. Organization of genetic material in prokaryote cells and in viruses. 7. Non-coding RNAs. 8. Protein biosynthesis. Post translational modifications of proteins. Mechanisms of protein transport and degradation. Proteomics. 9. Protein-protein, protein-nucleic acid and protein-lipid interactions. Supramolecular complexes. Molecular machines. 10. Intra- and intercellular interactions, receptor and signal transduction, ligand-receptor interactions. 11. Molecular bases of pathologies, including carcinogenesis, immunodeficiencies, autoimmune, neurodegenerative and other diseases of animals and humans. 12. Molecular virology and antiviral substances. 13. Genetic, protein and cell engineering, genomic engineering. 14. Visualization of macromolecules and macromolecular complexes in living cells. Study of the dynamics of intracellular processes in norm and pathology. 15. Molecular modeling, including prediction and design of protein structures, prediction of RNA secondary structures, modeling of dynamics of macromolecular complexes, modeling of protein-protein interactions, as well as interactions of proteins with low molecular weight compounds and nucleic acids in norm and pathology. 16. Development of new methods for studying molecular processes in living cells.